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1H-Indole-7-carboxaMide,2,3-dihydro-1-(3-hydroxypropyl)-5-[(2R)-2-[[2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethyl]aMino]propyl]-

Silodosin

CAS: 160970-54-7;160970-64-9

Molecular Formula: C25H32F3N3O4

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  5. 1H-Indole-7-carboxaMide,2,3-dihydro-1-(3-hydroxypropyl)-5-[(2R)-2-[[2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethyl]aMino]propyl]-

1H-Indole-7-carboxaMide,2,3-dihydro-1-(3-hydroxypropyl)-5-[(2R)-2-[[2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethyl]aMino]propyl]- - Names and Identifiers

Name Silodosin
Synonyms Urief
KAD 3213
KMD 3213
Silodoxin
Silodosin
Silodosin-d4
Silodosin API
1-(3-hydroxypropyl)-5-[(2R)-({2-[2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethyl}aMino)propyl]indoline-7-carboxaMide
1-(3-Hydroxypropyl)-5-[(2R)-2-[[2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethyl]amino]propyl]-2,3-dihydro-1H-indole-7-carboxamide
1-(3-hydroxypropyl)-5-[(2R)-2-({2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethyl}amino)propyl]-2,3-dihydro-1H-indole-7-carboxamide
1H-Indole-7-carboxamide,2,3-dihydro-1-(3-hydroxypropyl)-5-[(2R)-2-[[2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethyl]amino]propyl]-
1H-Indole-7-carboxaMide,2,3-dihydro-1-(3-hydroxypropyl)-5-[(2R)-2-[[2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethyl]aMino]propyl]-
(-)-1-(3-Hydroxypropyl)-5-[(2R)-2-[[2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethyl]amino]propyl]-2,3-di-hydro-1H-indole-7-carboxamide
CAS 160970-54-7
160970-64-9
EINECS 814-909-2
InChI InChI=1/C25H32F3N3O4/c1-17(30-8-12-34-21-5-2-3-6-22(21)35-16-25(26,27)28)13-18-14-19-7-10-31(9-4-11-32)23(19)20(15-18)24(29)33/h2-3,5-6,14-15,17,30,32H,4,7-13,16H2,1H3,(H2,29,33)/t17-/m1/s1

1H-Indole-7-carboxaMide,2,3-dihydro-1-(3-hydroxypropyl)-5-[(2R)-2-[[2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethyl]aMino]propyl]- - Physico-chemical Properties

Molecular FormulaC25H32F3N3O4
Molar Mass495.53
Density1.249±0.06 g/cm3(Predicted)
Melting Point>104°C (dec.)
Boling Point601.4±55.0 °C(Predicted)
Specific Rotation(α)D25 -14.0° (c = 1.01 in methanol)
Flash Point317.5°C
Solubility DMSO 99 mg/mL Water <1 mg/mL Ethanol 99 mg/mL
Vapor Presure2.58E-15mmHg at 25°C
AppearanceSolid
ColorWhite to Off-White
pKa14.85±0.10(Predicted)
Storage Conditionunder inert gas (nitrogen or Argon) at 2–8 °C
Refractive Index1.552
In vitro studySilodosin has a higher selectivity for the α(1A)-AR subtype than tamsulosin hydrochloride, naftopidil or prazosin hydrochloride (affinity tamsulosin hydrochloride is highest, followed by silodosin, prazosin hydrochloride or naftopidil). In human and rat isolated prostates, Silodosin and tadalafil have a synergistic inhibition of rat neuro-mediated contractile effects.
In vivo studyIn the lower urinary tract tissues of rabbits, Silodosin strongly antagonized norepinephrine-induced contractions (including prostate, urethra and bladder triangle, with PA(2) or pK B values of 9.60, respectively, 8.71 and 9.35). In rats, Silodosin was administered at 12 hours, 18 hours and 24 hours after oral administration. The phenylephrine-induced increase in intraurethral pressure (relative to the control treatment group) was significantly inhibited. Silodosin(0.1-0.3 mg/kg) or Prazosin(0.03-0.1 mg/kg) reduced the barrier-induced intraluminal ureteral pressure by 21-37% or 18-40%, respectively. Silodosin inhibits isolated rat and human ureteral contractions and has excellent functional selectivity to relieve pressure on obstructed ureters in loaded rats. In young and old dogs with benign prostatic hyperplasia, Silodosin(0.3-300 mg/kg) dose-dependently inhibited the increase in Urethral pressure induced by hypogastric nerve stimulation (no significant hypotensive effect).

1H-Indole-7-carboxaMide,2,3-dihydro-1-(3-hydroxypropyl)-5-[(2R)-2-[[2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethyl]aMino]propyl]- - Risk and Safety

HS Code29339900
1H-Indole-7-carboxaMide,2,3-dihydro-1-(3-hydroxypropyl)-5-[(2R)-2-[[2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethyl]aMino]propyl]-
Supplier List
Hubei YoungXin Pharmaceutical Tech Co.,Ltd.
Spot supply
Product Name: Silodosin Impurity 19 (rac-Silodosin) Visit Supplier Webpage Request for quotation
CAS: 160970-64-9
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CAS: 160970-64-9
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Shanghai Yuanye Bio-Technology Co., Ltd.
Multiple Specifications
Product Name: Silodosin Visit Supplier Webpage Request for quotation
CAS: 160970-54-7
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409 Click to send a QQ message
Wechat: 18301782025
Hubei YoungXin Pharmaceutical Tech Co.,Ltd.
Spot supply
Product Name: Silodosin Impurity 19 (rac-Silodosin) Visit Supplier Webpage Request for quotation
CAS: 160970-64-9
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052 Click to send a QQ message
Wechat: 15671228036
Hefei TNJ Chemical Industry Co.,Ltd.
Product Name: Silodosin Request for quotation
CAS: 160970-64-9
Tel: 0086-551-65418684
Email: sales@tnjchem.com
　　　　 info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840 Click to send a QQ message
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
Shanghai Yuanye Bio-Technology Co., Ltd.
Multiple Specifications
Product Name: Silodosin Visit Supplier Webpage Request for quotation
CAS: 160970-54-7
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409 Click to send a QQ message
Wechat: 18301782025
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1H-Indole-7-carboxaMide,2,3-dihydro-1-(3-hydroxypropyl)-5-[(2R)-2-[[2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethyl]aMino]propyl]-
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